histone deacetylase 8 (HDAC8, CDA07, HDACL1)

Function

• see histone deacetylase
• deacetylation of Lys on N-terminal part of core histones (H2A, H2B, H3 & H4)
• interacts with PEPB2-MYH11, a fusion protein produced by inversion inv(16)(p13q22)
• interacts with CBFA2T3

Inhibition:

• activity is inhibited by trichostatin A (TSA) & butyrate, two well known histone deacetylase inhibitors

Structure

• belongs to the histone deacetylase family, type 1 subfamily

Compartment

nucleus, excluded from the nucleoli

Alternative splicing

named isoforms=3

Expression

• weakly expressed in most tissues
• expressed at higher level in heart, brain, kidney & pancreas

More general terms

• histone deacetylase

Database

• OMIM: https://mirror.omim.org/entry/300269
• UniProt: http://www.uniprot.org/uniprot/Q9BY41.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=55869