zinc finger protein 423; olf1/EBF-associated Zn+2 finger protein; hOAZ; smad- & Olf-interacting zinc finger protein (ZNF423, KIAA0760, OAZ)
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Function
- transcription factor that can both act as an activator or a repressor depending on the context
- role in BMP signaling & olfactory neurogenesis
- associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes
- acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved in terminal olfactory receptor neuron differentiation; interaction prevents EBF1 binding DNA & activation of olfactory-specific genes
- involved in olfactory neurogenesis by participating in a developmental switch that regulates transition from differentiation to maturation in olfactory receptor neurons
- controls proliferation & differentiation of neural precursors in cerebellar vermis formation
- homodimer (putative)
- interacts with PARP1 & EBF1 (putative)
- interacts with SMAD1 & SMAD4
Structure
- uses different DNA- & protein-binding zinc fingers to regulate distinct BMP-Smad & Olf signaling pathways
- C2H2-type zinc fingers 14-19 mediate the interaction with SMAD1 & SMAD4
- zinc fingers 28-30 mediate interaction with EBF1
- zinc fingers 2-8 bind the 5'-CCGCCC-3' DNA sequence in concert with EBF1
- zinc fingers 9-13 bind BMP target gene promoters in concert with SMADs
- belongs to the krueppel C2H2-type zinc-finger protein family
- contains 30 C2H2-type zinc fingers
Compartment
Expression
- expressed in brain, lung, skeletal muscle, heart, pancreas & kidney but not liver or placenta
- also expressed in aorta, ovary, pituitary, small intestine, fetal brain, fetal kidney
- within the adult brain, expressed in the substantia nigra, medulla, amygdala, thalamus & cerebellum