transcription factor COE1; O/E-1; OE-1; early B-cell factor (EBF1, COE1, EBF)

Function

• transcriptional activator
• recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3' (putative)
• forms either a homodimer or a heterodimer with a related family member (putative)
• interacts with ZNF423 & ZNF521, leading to prevent EBF1 to bind DNA & activate target genes

Structure

• belongs to the COE family
• contains 1 IPT/TIG domain

Compartment

nucleus (putative)

Alternative splicing

named isoforms=2

More general terms

• COE family transcription factor

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1879
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1879
• OMIM: https://mirror.omim.org/entry/164343
• UniProt: http://www.uniprot.org/uniprot/Q9UH73.html