poly [ADP-ribose] polymerase 1; PARP-1; NAD(+) ADP-ribosyltransferase 1; ADPRT 1; poly[ADP-ribose] synthase 1 (PARP1, ADPRT, PPOL)
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Introduction
also see poly[ADP-ribose]polymerase
Function
- role in the base excision repair pathway, by catalyzing poly-ADP-ribosylation of a limited number of acceptor proteins involved in chromatin architecture & in DNA metabolism
- poly-ADP-ribosylation follows DNA damage & appears as an obligatory step in a detection/signaling pathway leading to repair of DNA double-strand breaks
- mediates poly-ADP-ribosylation of APLF & CHFR
- positively regulates transcription of MTUS1 & negatively regulates transcription of MTUS2/TIP150
- with EEF1A1 & TXK, forms a complex that acts as a Th1 cell-specific transcription factor & binds the promoter of IFN-gamma to directly regulate its transcription, & thus seves a role in Th1 cytokine production
- phosphorylated by PRKDC & TXK
- phosphorylated upon DNA damage, probably by ATM or ATR
- poly-ADP-ribosylated by PARP2
- poly-ADP-ribosylation mediates recruitment of CHD1L to DNA damage sites
- S-nitrosylated, inhibiting of transcription (putative)
- component of a base excision repair complex
- homodimer & heterodimer with PARP2
- interacts with PARP3, APTX & SRY
- component of SWAP complex
- interacts with TIAM2 & ZNF423 (putative)
- interacts (when poly-ADP-ribosylated) with CHD1L
- interacts with DNA polymerase alpha catalytic subunit POLA1;
- interaction functions in replication fork progression
- interacts with EEF1A1, RNF4 & TXK
Structure
- contains 1 BRCT domain
- contains 1 PARP alpha-helical domain
- contains 1 PARP catalytic domain
- contains 2 PARP-type Zn+2 fingers
Compartment
Notes
- the ADP-D-ribosyl group of NAD+ is transferred to an acceptor carboxyl group on a histone or the enzyme itself, & further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units
More general terms
Additional terms
Component of
References
- ↑ UniProt http://www.uniprot.org/uniprot/P09874.html
- ↑ NIEHS-SNPs http://egp.gs.washington.edu/data/adprt/