poly(ADP-ribose)glycohydrolase (pARG)

Function

• acts in concert with poly[ADP-ribose]polymerase to facilitate repair of DNA double strand breaks
• rapidly degrades poly(ADP-ribose) synthesized after DNA damage
• role in maintenance of neuronal cells (putative)
• hydrolyzes poly(ADP-ribose) at glycosidic (1''-2') linkage of ribose-ribose bond to produce free ADP-ribose

Compartment

• isoform 1: nucleus
• isoform 2 & 3: cytoplasm

Alternative splicing

named isoforms=3

Expression

ubiquitously expressed

More general terms

• nucleosidase
• phosphoprotein

More specific terms

• poly(ADP-ribose) glycohydrolase ARH3 ([protein ADP-ribosylarginine] hydrolase-like protein 2, ADP-ribosylhydrolase 3, ADPRHL2, ARH3)

Additional terms

• NAD+ ADP-ribosyltransferase or poly ADP-ribose polymerase

Database

• OMIM: https://mirror.omim.org/entry/603501
• UniProt: http://www.uniprot.org/uniprot/Q86W56.html