DNA polymerase alpha catalytic subunit (POLA1, POLA, DNA polymerase subunit A)

Function

• polymerase alpha in a complex with DNA primase is a replicative polymerase
• a 165 kD form is probably produced by proteolytic cleavage at Lys-124

deoxynucleoside triphosphate + DNA(n) <--> diphosphate + DNA(n+1)

Structure

belongs to the DNA polymerase type-B family

Compartment

nucleus

More general terms

• protein subunit
• nucleotidyltransferase
• zinc finger protein
• phosphoprotein

Component of

• DNA polymerase alpha

Database

• UniProt: http://www.uniprot.org/uniprot/P09884.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5422
• OMIM: https://mirror.omim.org/entry/312040