elongation factor 1-alpha 1 (EEF1A1)

Function

• promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
• qith PARP1 & TXK, forms a complex that acts as a T helper 1 (Th1 cell)-specific transcription factor
• binds the promoter of IFN-gamma to directly regulate its transcription,
• role Th1 cytokine production
• ISGylated
• phosphorylated by TXK
• phosphorylation by PASK increases translation efficiency
• found in a nuclear export complex with XPO5, EEF1A1, Ran & aminoacylated tRNA
• interacts with PARP1, TXK, XPO5 & KARS
• may interact with ERGIC2
• interacts with IFIT1 (via TPR repeats 4-7) (putative)
• interacts with DLC1, facilitating distribution to the membrane periphery & ruffles upon growth factor stimulation
• interacts with ZPR1 (EGF-manner)
• may mediate accelerated synthesis of free thiol-containing proteins in response to homocysteine-induced oxidative stress
• role in regulation of heat-shock repsonse

Structure

• belongs to the GTP-binding elongation factor family EF-Tu/EF-1A subfamily

Compartment

• cytoplasm. nucleus. nucleus, nucleolus
• colocalizes with DLC1 at actin-rich regions in the cell periphery
• translocates together with ZPR1 from the cytoplasm to the nucleus & nucleolus after treatment with mitogens

Expression

• expressed brain, placenta, lung, liver, kidney, pancreas
• barely detectable in heart & skeletal muscle
• induced by homocysteine (HC)

More general terms

• elongation factor 1-alpha

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1915
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1915
• OMIM: https://mirror.omim.org/entry/130590
• UniProt: http://www.uniprot.org/uniprot/P68104.html