PAS domain-containing serine/threonine protein kinase; PAS-kinase; PASKIN; hPASK (PASK, KIAA0135)

Function

• serine/threonine protein kinase
• activated by autophosphorylation on Thr-1161 & Thr-1165
• inhibited by the first PAS domain

Structure

• belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family
• contains 2 PAS (PER-ARNT-SIM) domains
• contains 1 protein kinase domain

Compartment

cytoplasm

Alternative splicing

named isoforms=2

Expression

• ubiquitously expressed

slightly higher expression in brain, prostate & testis

• lesser expression in placenta

More general terms

• serine/threonine kinase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23178
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:23178
• OMIM: https://mirror.omim.org/entry/607505
• UniProt: http://www.uniprot.org/uniprot/Q96RG2.html