elongation factor Tu, mitochondrial; EF-Tu; P43 (TUFM)

Function

• promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis

Structure

• belongs to the GTP-binding elongation factor family, EF-Tu/EF-1A subfamily

Compartment

mitochondria

Pathology

• defects in TUFM are the cause of combined oxidative phosphorylation deficiency type 4

More general terms

• mitochondrial protein
• translation elongation factor

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7284
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7284
• OMIM: https://mirror.omim.org/entry/602389
• OMIM: https://mirror.omim.org/entry/610678
• UniProt: http://www.uniprot.org/uniprot/P49411.html