aprataxin & PNK-like factor (APLF C2orf13)

Function

• role in single-strand & double-strand DNA break repair
• interacts with XRCC1
• may also interact with XRCC4 & XRCC5
• phosphorylated in an ATM-dependent manner upon double-strand DNA break

Structure

• contains 2 C2H2-type zinc fingers
• contains 1 FHA-like domain mediates interaction with XRCC1 & XRCC4

Compartment

• nucleus, cytoplasm
• colocalizes with XRCC1 at sites of DNA damage

More general terms

• C2H2 type zinc finger protein
• phosphoprotein
• nuclear protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q8IW19.html