DNA repair protein XRCC1; X-ray repair cross-complementing protein 1 (XRCC1)

Function

• corrects defective DNA strand-break repair & sister chromatid exchange following treatment with ionizing radiation & alkylating agents
• phosphorylation of Ser-371 causes dimer dissociation
• phosphorylation by CK2 promotes interaction with APTX & APLF
• sumoylated
• interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB) & DNA ligase 3 (LIG3)
• interacts with APTX & APLF

Structure

• homodimer
• contains 2 BRCT domains

Compartment

• nucleus
• accumulates at sites of DNA damage

Polymorphism

• carriers of the polymorphic Gln-399 allele may be at greater risk for tobacco- & age-related DNA damage

More general terms

• nuclear protein
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/P18887.html
• OMIM: https://mirror.omim.org/entry/194360