DNA polymerase beta (POLB, DNA polymerase X)

Function

• repair polymerase
• complexes with DNAase V
• may remove primers & fill gaps between Okasaki fragments.
• DNA polymerase-beta is the polymerase of base excision repair
• has a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity

Cofactor: binds 2 Mg+2 per subunit (putative)

Structure

• monomer
• residues 239-252 form a flexible loop which appears to affect the polymerase fidelity (putative)
• belongs to the DNA polymerase type-X family

Compartment

nucleus

More general terms

• DNA polymerase
• exoribonuclease

Additional terms

• DNA base excision repair

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5423
• OMIM: https://mirror.omim.org/entry/174760
• UniProt: http://www.uniprot.org/uniprot/P06746.html