DNA ligase-3 (LIG3)

Function

• interacts with DNA-repair protein XRCC1
• can correct defective DNA strand-break repair & sister chromatid exchange following treatment with ionizing radiation & alkylating agents

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m)
                     <-->
AMP + diphosphate + (deoxyribonucleotide)(n+m)

Structure

• belongs to the ATP-dependent DNA ligase family
• contains 1 BRCT domain
• contains 1 PARP-type Zn+2 finger

Compartment

nucleus

Alternative splicing

named isoforms=2

Expression

testis, thymus, prostate & heart

More general terms

• ATP-dependent DNA ligase
• phosphoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3980
• OMIM: https://mirror.omim.org/entry/600940
• UniProt: http://www.uniprot.org/uniprot/P49916.html