polynucleotide kinase (PNK)
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Function
- possesses 3' DNA phosphatase & 5' DNA kinase activity
- both activities stimulated by XRCC1 at damaged DNA termini
- XRCC1, polynucleotide kinase, DNA ligase III & DNA polymerase beta associate in a multiprotein complex
More general terms
References
- ↑ Whitehouse CJ et al XRCC1 stimulates human polynucleotide kinase activity at damaged DNA termini and accelerates DNA single-strand break repair. Cell 104:107-17 2001 PMID: https://www.ncbi.nlm.nih.gov/pubmed/11163244
- ↑ OMIM https://mirror.omim.org/entry/605610