mitochondrial tumor suppressor 1 (angiotensin-2 type 2 receptor-interacting protein, MTUS1, ATIP, GK1, KIAA1288, MTSG1)

Function

• cooperates with AGTR2 to inhibit ERK2 activation & cell proliferation
• may be required for AGTR2 cell surface expression
• together with PTPN6, induces UBE2V2 expression upon angiotensin-2 stimulation
• interacts with AGTR2
• interacts with PTPN6

Structure

• homodimer
• belongs to the MTUS1 family

Compartment

• mitochondria, Golgi, cell membrane, nucleus
• in neurons, translocates into the nucleus after treatment with angiotensin-2 (putative)

Alternative splicing

named isoforms=6

Expression

• ubiquitously expressed (at protein level)
• ighly expressed in brain

Pathology

• down-regulated in ovarian carcinoma, pancreas carcinoma, colon carcinoma & head & neck squamous cell carcinoma
• defects in MTUS1 may be a cause of hepatocellular carcinoma

More general terms

• phosphoprotein
• mitochondrial protein

Database

• OMIM: https://mirror.omim.org/entry/114550
• UniProt: http://www.uniprot.org/uniprot/Q9ULD2.html