ubiquitin-conjugating enzyme E2 variant 2; DDvit 1; enterocyte differentiation-associated factor 1; EDAF-1; enterocyte differentiation-promoting factor 1; EDPF-1; MMS2 homolog; vitamin D3-inducible protein (UBE2V2, MMS2, UEV2)

Function

• has no ubiquitin ligase activity on its own
• UBE2V2/UBE2N heterodimer catalyzes synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63
• this type of poly-ubiquitination does not lead to protein degradation by the proteasome
• mediates transcriptional activation of target genes
• role in control of cell cycle progression & differentiation
• role in error-free DNA repair
• contributes to survival of cells after DNA damage
• heterodimer with UBE2N
• binds CHFR

Structure

• belongs to the ubiquitin-conjugating enzyme family

Expression

• detected in placenta, colon, liver & skin
• detected at very low levels in most tissues
• up-regulated in cultured fresh blood cells upon treatment with vitamin D3

More general terms

• ubiquitin-conjugating protein E2 (ubiquitin carrier protein)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7336
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7336
• OMIM: https://mirror.omim.org/entry/603001
• UniProt: http://www.uniprot.org/uniprot/Q15819.html