angiotensin II receptor type-2; AT2 (AGTR2)
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Function
- receptor for angiotensin II
- cooperates with MTUS1 to inhibit ERK2 activation & cell proliferation
- interacts with MTUS1
- AGTR2 may play a role in neuropathic pain
Structure
belongs to the G-protein coupled receptor 1 family
Compartment
cell membrane; multi-pass membrane protein
Expression
- in adult, highly expressed in myometrium with lower levels in adrenal gland & fallopian tube
- very highly expressed in fetal kidney & intestine
Pharmacology
- AGTR2 antagonist EMA401 may be useful for treating postherpetic neuralgia/neuropathic pain[3]
More general terms
Additional terms
- angiotensin II receptor type 2 & 4-inhibiting antihypertensive
- angiotensin II receptor type 2 & 4-stimulating antihypertensive
References
- ↑ UniProt http://www.uniprot.org/uniprot/P50052.html
- ↑ GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=AGTR2
- ↑ 3.0 3.1 Rice AS et al EMA401, an orally administered highly selective angiotensin II type 2 receptor antagonist, as a novel treatment for postherpetic neuralgia: a randomised, double-blind, placebo- controlled phase 2 clinical trial. The Lancet, Early Online Publication, 5 February 2014 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/24507377 <Internet> http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2813%2962337-5/abstract