tyrosine-protein phosphatase 6, non-receptor type; protein-tyrosine phosphatase 1C; PTP-1C; hematopoietic cell protein-tyrosine phosphatase; SH-PTP1; protein-tyrosine phosphatase SHP-1 (PTPN6, HCP, PTP1C)

^[1]^[2]^[3]^[4]

Function

plays a key role in hematopoiesis
may directly link growth factor receptors & other signaling proteins through protein-tyrosine phosphorylation
SH2 containing tyrosin phosphatases may act preferentially on substrates that are phosphorylated on more than one Tyr
interaction of their SH2 domain(s) with phosphorylated Tyr(s) may position the enzyme to hydrolyze unprotected phospho-Tyr
SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates
together with MTUS1, induces UBE2V2 expression upon angiotensin 2 stimulation
phosphorylated on Ser & Tyr
activity may be non-specific

monomer
interacts with MTUS1
binds PTPNS1, LILRB1 & LILRB2
interacts with FCRL2, FCRL3, FCRL4, CD300LF & CD84
belongs to the protein-tyrosine phosphatase family non-receptor class 2 subfamily
contains 2 SH2 domains
contains 1 tyrosine-protein phosphatase domain

cytoplasm. nucleus
in neurons, translocates into the nucleus after treatment with angiotensin 2 (putative)

↑ Feng GS, Hui CC, Pawson T. SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases. Science. 1993 Mar 12;259(5101):1607-11. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8096088
↑ Vogel W, Lammers R, Huang J, Ullrich A. Activation of a phosphotyrosine phosphatase by tyrosine phosphorylation. Science. 1993 Mar 12;259(5101):1611-4. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7681217
↑ Ahmad S, Banville D, Zhao Z, Fischer EH, Shen SH. A widely expressed human protein-tyrosine phosphatase containing src homology 2 domains. Proc Natl Acad Sci U S A. 1993 Mar 15;90(6):2197-201. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7681589
↑ UniProt http://www.uniprot.org/uniprot/P29350.html