leukocyte immunoglobulin-like receptor subfamily B member 1; leukocyte immunoglobulin-like receptor 1; LIR-1; immunoglobulin-like transcript 2; ILT-2; monocyte/macrophage immunoglobulin-like receptor 7; MIR-7; CD85 antigen-like family member J; CD85j (LILRB1, ILT2, LIR1, MIR7)

Function

• receptor for class 1 MHC antigens
• recognizes a broad spectrum of HLA-A, HLA-B, HLA-C & HLA-G alleles
• receptor for H301/UL18, a human cytomegalovirus class 1 MHC homolog
• ligand binding results in inhibitory signals & down-regulation of the immune response
• ngagement of LILRB1 present on NK-cells or T-cells by class 1 MHC molecules protects the target cells from lysis
• interaction with HLA-B or HLA-E leads to inhibition of the signal triggered by FCER1A & inhibits serotonin release
• inhibits FCGR1A-mediated phosphorylation of cellular proteins & mobilization of intracellular Ca+2
• phosphorylated on Tyr
• dephosphorylated by PTPN6
• binds PTPN6 when phosphorylated
• binds FCER1A & FCGR1A

Structure

• contains 4 ITIM motif in the cytoplasmic domain
• phosphorylated ITIM motif can bind the SH2 domain of several SH2 domain-containing phosphatases
• contains 4 Ig-like C2-type domains (immunoglobulin-like)
• related to known NK-cell killer inhibitory receptors

Compartment

• membrane; single-pass type 1 membrane protein

Alternative splicing

named isoforms=3

Expression

• expressed predominantly on B-cells & monocytes
• expressed at lower levels on dendritic cells
• detected on a low percentage of T-cells & NK-cells

More general terms

• CD85 or leukocyte immunoglobulin-like receptor family protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10859
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10859
• OMIM: https://mirror.omim.org/entry/604811
• UniProt: http://www.uniprot.org/uniprot/Q8NHL6.html