immunoreceptor tyrosine-based inhibitory motif (ITIM)

Introduction

Motifs in cytoplasmic domains of inhibitory receptors, involved in modulation of cellular responses. The phosphorylated ITIM motif can recruit SH2 domain-containing protein-tyrosine phosphatases, resulting in inactivation of NK cells.

More general terms

• peptide motif
• domain

Additional terms

• immunoreceptor tyrosine-based activator motif (ITAM)
• ITIM-like motif