tyrosine-protein phosphatase non-receptor type substrate 1; SHP substrate 1; SHPS-1; brain Ig-like molecule with tyrosine-based activation motifs; Bit; CD172 antigen-like family member A; inhibitory receptor SHPS-1; macrophage fusion receptor; MyD-1 antigen; signal-regulatory protein alpha-1; Sirp-alpha-1; signal-regulatory protein alpha-2; Sirp-alpha-2; signal-regulatory protein alpha-3; Sirp-alpha-3; p84; CD172a (SIRPA, BIT, MFR, MYD1, PTPNS1, SHPS1, SIRP)

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Function

immunoglobulin-like cell surface receptor for CD47
acts as docking protein & induces translocation of PTPN6, PTPN11 & other binding partners from the cytosol to the plasma membrane
supports adhesion of cerebellar neurons, neurite outgrowth & glial cell attachment
may play a key role in intracellular signaling during synaptogenesis & in synaptic function
role negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin
mediates negative regulation of phagocytosis, mast cell activation & dendritic cell activation
CD47 binding prevents maturation of immature dendritic cells & inhibits cytokine production by mature dendritic cells
phosphorylated on Tyr in response to stimulation with EGF, growth hormone, insulin & PDGF
dephosphorylated by PTPN11
binds PTPN11 when Tyr-phosphorylated, except in macrophages, where it primarily binds PTPN6
binds GRB2 in vitro
binds FGR (putative)
binds JAK2 independent of its phosphorylation status & forms a stable complex
binds SCAP1 &/or SCAP2; the resulting complex recruits FYB
binds PTK2B

ubiquitous
highly expressed in brain
detected on myeloid cells, but not T-cells
detected at lower levels in heart, placenta, lung, testis, ovary, colon, liver, small intestine, prostate, spleen, kidney, skeletal muscle & pancreas