FYN-binding protein; FYN-T-binding protein; FYB-120/130; p120/p130; SLP-76-associated phosphoprotein; SLAP-130; Adhesion & degranulation promoting adaptor protein; ADAP (FYB, SLAP130)

Function

• acts as an adapter protein of the FYN & LCP2 signaling cascades in T cells
• modulates expression of interleukin-2 (IL-2)
• involved in platelet activation
• prevents the degradation of SKAP1 & SKAP2
• T-cell receptor ligation leads to increased Tyr phosphorylation
• part of a complex consisting of SKAP2, FYB & PTPNS1
• part of a complex consisting of SKAP2, FYB & LILRB3
• interacts with FYN, LCP2, SKAP1 & SKAP2

Structure

contains 1 SH3 domain

Compartment

cytoplasm. nucleus (putative)

Alternative splicing

named isoforms=2; FYB-120, FYB-130

Expression

• expressed in hematopoietic tissues such as myeloid & T-cells, spleen & thymus
• not expressed in B-cells, non-lymphoid tissues

More general terms

• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2533
• OMIM: https://mirror.omim.org/entry/602731
• UniProt: http://www.uniprot.org/uniprot/O15117.html