lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kD, SLP-76 tyrosine phosphoprotein, SLP76, LCP2)

Function

• role in T-cell antigen receptor mediated signaling
• interacts with SLA, CBLB, adapter proteins GRB2 & FYB, SHB
• SH2 domain mediates interaction with SHB
• phosphorylated after T-cell receptor activation by ZAP-70

Structure

• contains 1 SH2 domain

Compartment

cytoplasm

Expression

• expressed in spleen, thymus, peripheral blood leukocytes
• expressed in T-cell & monocytic cell lines > B-cell lines
• not expressed in fibroblast or neuroblasatoma cell lines

More general terms

• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/601603
• UniProt: http://www.uniprot.org/uniprot/Q13094.html