src kinase-associated phosphoprotein 2 (src family-associated phosphoprotein 2, src kinase-associated phosphoprotein 55-related protein, SKAP55 homolog, SKAP-HOM, SKAP-55HOM, src-associated adapter protein with PH & SH3 domains, Pyk2/RAFTK-associated protein, retinoic acid-induced protein 70, SKAP2, PRAP, RA70, SAPS, SCAP2, SKAP55R)
Jump to navigation
Jump to search
Function
- role in B-cell & macrophage adhesion processes
- in B-cells, may act by coupling the B-cell receptor to integrin activation
- role in src signaling pathway (putative)
- interacts with PTPNS1
- component of complex consisting of SKAP2, FYB & PTPNS1
- component of complex consisting of SKAP2, FYB & LILRB3
- may interact with actin
- interaction with FYB required for SKAP2 protein stability
- interacts with LAT, GRB2, PTK2B & PRAM1
- may interact with FYN, HCK & LYN
- phosphorylated in resting platelets
- phosphorylated by FYN on Tyr-261 upon T-cell activation
Structure
- belongs to the SKAP family
- contains 1 PH domain
- contains 1 SH3 domain, interacts with FYB & PTK2B
Compartment
Expression
- ubiquitously expressed
- present in platelets
- induced by retinoic acid