PML-RARA-regulated adapter molecule 1 (PRAM-1, PRAM, PRAM1)

Function

• role in myeloid differentiation
• role in integrin signaling in neutrophils
• binds to PtdIns(4)P cy SH3 domain
• interacts with SKAP2, LCP2 & DBNL
• may interact with LYN
• may be phosphorylated on tyrosines

Structure

• contains 1 SH3 domain

Alternative splicing

named isoforms=2

Expression

• expressed in peripheral blood leukocytes, bone marrow
• expressed in monocytes > granulocytes, lymphocytes
• not expressed in non hematopoietic tissues except in lung
• down-regulated by the fusion protein PML-RARA

More general terms

• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/606466
• UniProt: http://www.uniprot.org/uniprot/Q96QH2.html