PML-RAR alpha fusion protein

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Introduction

product of translocation t(15;17)(q21;q21), seen in some cases of acute promyelocytic leukemia. represses transcription by associating with a corepressor complex containing histone deacetylase activity[1]

More general terms

References

  1. 1.0 1.1 Marks et al. Nature Reviews Cancer 1:194-202, 2001