focal adhesion kinase 2 (protein tyrosine kinase 2 beta, FADK 2, proline-rich tyrosine kinase 2, cell adhesion kinase beta, CAK beta, Ca+2-dependent tyrosine kinase, CADTK, related adhesion focal tyrosine kinase, RAFTK, PTK2B, FAK2, PYK2, RAFTK)

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Function

role in Ca+2 induced regulation of ion channel(s) & activation of the MAP kinase signalling pathway
may represent signaling intermediate between neuropeptide activated receptors or neurotransmitters that increase Ca+2 flux & the downstream signals that regulate neuronal activity
interacts with the SH2 domain of Grb2
may phosphorylate the voltage-gated K+ channel protein Kv1.2
its activation is highly correlated with the stimulation of c-Jun N-terminal kinase activity
role in osmotic stress-dependent SNCA Tyr-125 phosphorylation
interacts with Crk-associated substrate (Cas), PTPNS1 & SH2D3C (putative)
interacts with nephrocystin, DDEF2, OPHN1L, SKAP2 & TGFB1I1
phosphorylated on Tyr in response to various stimuli that elevate intracellular Ca+2 concentration, as well as by PKC activation
recruitment by nephrocystin to cell matrix adhesions initiates Tyr-402 phosphorylation
in monocytes, adherence to substrata is required for tyrosine phosphorylation & kinase activation
angiotensin 2, thapsigargin & L-alpha-lysophosphatidic acid also induce autophosphorylation & increase kinase activity (putative)

ATP + a [protein]-L-tyrosine
            <-->
ADP + a [protein]-L-tyrosine phosphate

belongs to the protein kinase superfamily, Tyr protein kinase family, FAK subfamily
contains 1 FERM domain contains 1 protein kinase domain