Rho GTPase-activating protein 26; GTPase regulator associated with focal adhesion kinase; oligophrenin-1-like protein; Rho-type GTPase-activating protein 26 (ARHGAP26, GRAF, KIAA0621, OPHN1L)

Function

• GTPase-activating protein for RHOA & CDC42
• binds to the C-terminus of PTK2/FAK

Structure

• contains 1 PH domain
• contains 1 Rho-GAP domain
• contains 1 SH3 domain

Compartment

• cell junction, focal adhesion
• cytoplasm, cytoskeleton (putative)
• colocalizes with actin stress fibers & cortical actin structures (putative)

Alternative splicing

named isoforms=2

Pathology

• defects in ARHGAP26 are a cause of juvenile myelomonocytic leukemia

More general terms

• rho GTPase-activating protein (rho-GAP)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23092
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:23092
• OMIM: https://mirror.omim.org/entry/605370
• OMIM: https://mirror.omim.org/entry/607785
• UniProt: http://www.uniprot.org/uniprot/Q9UNA1.html