development & differentiation-enhancing factor 2; Pyk2 C-terminus-associated protein; PAP; paxillin-associated protein with ARFGAP activity 3; PAG3 (DDEF2, ASAP2, KIAA0400)

Function

• activates small GTPases ARF1, ARF5, ARF6
• regulates formation of post-Golgi vesicles
• modulates constitutive secretion
• modulates phagocytosis mediated by Fc gamma receptor & ARF6
• modulates PXN recruitment to focal contacts, cell migration
• binds PXN, ARF1, ARF5, ARF6, PTK2B, SRC

Compartment

• cytoplasm, Golgi, cell membrane
• colocalizes with F-actin, ARF6 in phagocytic cups

Alternative splicing

named isoforms=2

Expression

• detected in heart, brain, placenta, kidney, monocytes, pancreas
• up-regulated during monocyte maturation

More general terms

• other protein

Database

• OMIM: https://mirror.omim.org/entry/603817
• UniProt: http://www.uniprot.org/uniprot/O43150.html