Paxillin (PXN)
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Function
- cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion)
- binds in vitro to vinculin
- proline-rich region of paxillin binds to the SH3 domain of c-SRC &
- when Tyr phosphorylated, binds to the SH2 domain of Csk & Crk
- isoform beta binds to focal adhesion kinase but weakly to vinculin
- isoform gamma binds to vinculin but only weakly to focal adhesion kinase
- interacts with GIT1, NUDT16L1/SDOS, PARVA & TGFB1I1
- component of cytoplasmic complexes, which also contain GIT1, ARHGEF6 & PAK1 (putative)
- binds ASAP2
- interacts with unphosphorylated ITGA4
- interacts with RNF5 phosphorylated on Tyr during integrin- mediated cell adhesion, embryonic development, fibroblast transformation & following stimulation of cells by mitogens
Structure
- belongs to the paxillin family
- contains 4 LIM Zn+2-binding domains
Compartment
Alternative splicing
named isoforms=3; alpha, beta, gamma
More general terms
References
- ↑ Stossel TP. On the crawling of animal cells. Science. 1993 May 21;260(5111):1086-94. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8493552
- ↑ Saltiel AR. The paradoxical regulation of protein phosphorylation in insulin action. FASEB J. 1994
- ↑ Clark EA & Brugge JS Integrins and signal transduction pathways: the road taken. Science 268:233 1995 PMID: https://www.ncbi.nlm.nih.gov/pubmed/7716514
- ↑ UniProt http://www.uniprot.org/uniprot/P49023.html