E3 ubiquitin-protein ligase RNF5 (HsRma1, RING finger protein 5, protein G16, RNF5, G16, NG2, RMA1)

Function

• E2-dependent E3 ubiquitin-protein ligase activity
• may function together with E2 ubiquitin-conjugating enzymes UBE2D1/UBCH5A & UBE2D2/UBC4
• mediates ubiquitination of PXN/paxillin
• may be involved in regulation of cell motility & localization of PXN/paxillin
• interacts with PXN

Structure

• contains 1 RING-type zinc finger

Compartment

• membrane, plasma membrane (majority)
• cytoplasmic organelles

Expression

widely expressed

Pathology

• interacts with Salmonella typhimurium sopA
  • mediates ubiquitination of sopA

More general terms

• E3 ubiquitin ligase
• ring finger protein
• membrane protein

Database

• OMIM: https://mirror.omim.org/entry/602677
• UniProt: http://www.uniprot.org/uniprot/Q99942.html