ubiquitin-conjugating enzyme E2 D2; ubiquitin carrier protein D2; ubiquitin-conjugating enzyme E2(17)KB 2; ubiquitin-conjugating enzyme E2-17 kD 2; ubiquitin-protein ligase D2 (UBE2D2, UBC4, UBC5B, UBCH4, UBCH5B)

Function

• accepts ubiquitin from the E1 complex & catalyzes its covalent attachment to other proteins
• in vitro catalyzes Lys-48-linked polyubiquitination
• mediates the selective degradation of short-lived & abnormal proteins
• functions in the E6/E6-AP-induced ubiquitination of p53/TP53
• mediates ubiquitination of PEX5 & autoubiquitination of STUB1 & TRAF6
• roles in:
  • signal-induced conjugation & subsequent degradation of NFKBIA
  • FBXW2-mediated GCM1 ubiquitination & degradation
  • MDM2-dependent degradation of p53/TP53
  • activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection
• essential for viral activation of IRF3
• protein modification; protein ubiquitination
• interacts with SCF E3 ubiquitin ligase complex & with E3 ubiquitin-protein ligase PJA2
• interacts with PDZRN3 (putative)
• interacts with CNOT4 (via RING domain)

Structure

belongs to the ubiquitin-conjugating enzyme family

More general terms

• ubiquitin-conjugating protein E2 (ubiquitin carrier protein)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7322
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7322
• OMIM: https://mirror.omim.org/entry/602962
• UniProt: http://www.uniprot.org/uniprot/P62837.html