SCF-type E3 ligase complex

Function

• mediates ubiquitination & subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction & transcription

Structure

• subunits include: SKP1, RBX1, CUL1

More general terms

• molecular complex

More specific terms

• SCF(NIPA) E3 ligase complex
• SKP1-CUL1-F-box protein (SCF) complex; SCF(FBXW11) E3 ligase complex; CF(SKP2) E3 ligase complex

Additional terms

• E3 ubiquitin ligase; ubiquitin-ligating enzyme E3; N end-recognizing protein