S-phase kinase-associated protein 1; cyclin-A/CDK2-associated protein p19; p19skp1; p19A; RNA polymerase II elongation factor-like protein; organ of corti protein 2; OCP-2; organ of corti protein II; OCP-II; transcription elongation factor B; SIII (SKP1, EMC19, OCP2, SKP1A, TCEB1L)

Function

• component of the SCF complex which mediates ubiquitination & subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction & transcription
• in the SCF complex, serves as an adapter that links the F-box protein to CUL1
• interacts with the cyclin A/CDK2 complex
• part of a SCF- like complex consisting of CUL7, RBX1, SKP1 & FBXW8
• component of an E3 ubiquitin ligase complex containing UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC & TBL1X
• component of the SCF(BTRC) complex, composed of SKP1, CUL1 & BTRC
• part of a SCF(BTRC)-like complex lacking CUL1, which is associated with phosphorylated NFKBIA & RELA

Structure

belongs to the SKP1 family

Alternative splicing

named isoforms=2

More general terms

• Skp (S phase kinase associated protein) family protein

Additional terms

• cyclin A
• cyclin-dependent kinase-2 (CDK2)

Component of

• SKP1-CUL1-F-box protein (SCF) complex; SCF(FBXW11) E3 ligase complex; CF(SKP2) E3 ligase complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6500
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6500
• OMIM: https://mirror.omim.org/entry/601434
• UniProt: http://www.uniprot.org/uniprot/P63208.html