Cullin-7; CUL-7 (CUL7, KIAA0076)

Function

• component of a probable SCF-like E3 ubiquitin ligase
  • ubiquitin conjugation, 3rd step
• degradation of proteins involved in endothelial proliferation &/or differentiation
• does not seem to promote polyubiquitination & proteosomal degradation of TP53
• in vitro, complexes of CUL7 with either CUL9 or FBXW8 or TP53 contain E3 ubiquitin-protein ligase activity
• protein modification; protein ubiquitination
• component of SCF-like complex (CUL7-RBX1-SKP1-FBXW8 complex)
• interacts with a complex of SKP1 & FBXW8, but not with SKP1 alone
• interacts with CUL9
• interacts with FBXW8; interaction is mutually exclusive of binding to CUL9 or TP53
• interacts with TP53; the interaction preferentially involves tetrameric & dimeric TP53
• the CUL7-CUL9 heterodimer seems to interact specifically with TP53
• interacts with CUL1; the interactions seems to be mediated by FBXW8 (putative)

Structure

• belongs to the cullin family
• contains 1 DOC domain

Compartment

cytoplasm

Expression

• expressed in fetal kidney, skeletal muscle, fetal brain, adult pancreas, kidney, placenta, heart
• expressed in trophoblasts, lymphoblasts, osteoblasts, chondrocytes & skin fibroblasts

Pathology

• defects in CUL7 are the cause of 3M syndrome

More general terms

• cullin
• cell surface receptor
• phosphoprotein

Component of

• CUL7-RBX1-SKP1-FBXW8 complex (SCF-like complex)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9820
• OMIM: https://mirror.omim.org/entry/273750
• OMIM: https://mirror.omim.org/entry/609577
• UniProt: http://www.uniprot.org/uniprot/Q14999.html