calcyclin-binding protein (CacyBP, hCacyBP, Siah-interacting protein, S100A6-binding protein, CACYBP, S100A6BP, SIP, PNAS-107)

Function

• involved in Ca+2-dependent ubiquitination & subsequent proteosomal degradation of target proteins
• serves as a molecular bridge in ubiquitin E3 complexes
• ubiquitin-mediated degradation of beta-catenin
• interacts with proteins of the S100 family: S100A1, S100A6, S100B, S100P, S100A12
• component of some large E3 complex
• interacts directly with SIAH1, SIAH2, SKP1A
• phosphorylated on Ser
• phosphorylated upon induction by retinoic acid or at high Ca+2
• at low Ca+2 concentrations, nuclear fraction may be phosphorylated

Compartment

nucleus, cytoplasm

Alternative splicing

named isoforms=2

More general terms

• other protein

Component of

• some large E3 complex

Database

• OMIM: https://mirror.omim.org/entry/606186
• UniProt: http://www.uniprot.org/uniprot/Q9HB71.html