protein S100-A6; S100 Ca+2-binding protein A6; calcyclin; prolactin receptor-associated protein; PRA; growth factor-inducible protein 2A9; MLN 4 (S100A6, CACY)

Function

• interacts with SUGT1

Structure

• homodimer, antiparallel
• the N-terminus is blocked
• belongs to the S-100 family
• contains 2 EF-hand domains

Expression

• preferentially expressed when quiescent fibroblasts are stimulated to proliferate
• inducible by growth factors

Pathology

• overexpressed in acute myeloid leukemias

Notes

co-purified with prolactin receptor

More general terms

• Ca+2 binding protein

Additional terms

• S100 Ca+2-binding protein

Database

• UniProt: http://www.uniprot.org/uniprot/P06703.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6277
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6277
• OMIM: https://mirror.omim.org/entry/114110
• UniProt: http://www.uniprot.org/uniprot/P06703.html