prolactin receptor; PRL-R (PRLR)

Function

• receptor for prolactin
• isoforms 4 & 6 are unable to transduce prolactin signaling
• interacts with SMARCA1
• interacts with GH1

Structure

• the WSXWS motif essential for
  • proper protein folding
  • efficient intracellular transport
  • cell-surface receptor binding
• box 1 motif is required for JAK interaction &/or activation
• belongs to the type 1 cytokine receptor family, type 1 subfamily
• contains 2 fibronectin F3 modules

Compartment

membrane, secreted

Alternative splicing

• named isoforms=8
• soluble isoform that appears specific for the BT-474 breast cancer cell line

Expression

• expressed in breast, placenta, kidney, liver & pancreas

More general terms

• receptor
• glycoprotein
• membrane protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5618
• OMIM: https://mirror.omim.org/entry/176761
• UniProt: http://www.uniprot.org/uniprot/P16471.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5618