global transcription activator SNF2L1; nucleosome-remodeling factor subunit SNF2L; ATP-dependent helicase SMARCA1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1 (SMARCA1, SNF2L, SNF2L1)

Function

• energy-transducing component of:
  • nucleosome-remodeling factor complex (NURF)
  • CECR2-containing-remodeling factor complex (CERF)
• both complexes facilitate perturbation of chromatin structure (ATP-dependent)
• potentiates neurite outgrowth
• may be involved in brain development by regulating En-1 & En-2 expression
• may be involved in the development of luteal cells
• interacts with PRLR

Structure

• belongs to the SNF2/RAD54 helicase family, ISWI subfamily
• contains 1 helicase ATP-binding domain
• contains 1 helicase C-terminal domain
• contains 2 SANT domains

Compartment

nucleus

Alternative splicing

named isoforms=2

Notes

• isoform containing exon 13 is inactive as an ATPase & a chromatin remodeler, but retains its ability to incorporate into the NURF complex; it is predominant in non neuronal tissues

More general terms

• helicase (DNA unwinding protein, DNA untwisting protein)

Database

• UniProt: http://www.uniprot.org/uniprot/P28370.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6594
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6594
• OMIM: https://mirror.omim.org/entry/300012