WSXWS motif

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Introduction

Associated with 2 disulfide bridges in ligand-binding domain of hematopoietin receptor superfamily proteins. May facilitate hinge region. Tryptophans apparently involved in hydrophobic binding with ligand.

More general terms

Additional terms

References

  1. Idzerda RL et al, Human interleukin 4 receptor confers biological responsiveness and defines a novel receptor superfamily. J Exp Med 1990 Mar 1;171(3):861-73 PMID: https://www.ncbi.nlm.nih.gov/pubmed/2403843