S100 Ca+2-binding protein

Structure

• occurs as dimer of two alpha, two beta or one alpha & one beta subunit(s)

Compartment

found in nucleus & cytoplasm

Expression

• melanocytes
• breast
  • myoepithelial cells
  • microglandular adenosis
  • sclerosing adenosis, tubular carcinoma: -
  • ductal carcinoma: 46% +

Pathology

• found in:
  • melanoma
  • clear cell sarcoma
  • gliomas
  • peripheral nerve sheath tumors
  • chordoma
  • Langerhans cell lesions
  • chondrosarcoma
  • liposarcoma - lipoblasts
  • GIST: 10-20% +
  • gastric adenocarcinoma: 20% +, < 25% of cells
  • granular cell tumors

Laboratory

widely used for immunohistochemistry analyses

More general terms

• Ca+2 binding protein
• multisubunit protein

Additional terms

• protein S100-P; S100 Ca+2-binding protein P (S100P S100E)
• S100 Ca+2-binding protein A