protein S100-A12; Ca+2-binding protein in amniotic fluid 1; CAAF1; calgranulin-C; CAGC; extracellular newly identified RAGE-binding protein; EN-RAGE; neutrophil S100 protein; S100 Ca+2-binding protein A12; p6; contains: calcitermin (S100A12)

Function

• calcitermin
  • possesses antifungal activity against C albicans
  • possesses antibacterial activity against E coli & P aeruginosa
  • not active agains L monocytogenes & S aureus
• binds Ca+2, Zn+2 & copper
• presence of Zn+2 increases the affinity for Ca+2
• role in the inflammatory response
• interaction with AGER on endothelium, mononuclear phagocytes, & lymphocytes triggers cellular activation, with generation of key proinflammatory mediators (putative)
  • interacts with AGER
    • both Ca+2 & Zn+2 are essential for the interaction

Structure

• homooligomer (tetramer or hexamer) in the presence of Ca+2 & Zn+2
• belongs to the S-101 family
• contains 2 EF-hand domains

Expression

• expressed & secreted by monocytes & lymphocytes

More general terms

• calgranulin (MIF-related protein, cystic fibrosis antigen)
• S100 Ca+2-binding protein A

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6283
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6283
• OMIM: https://mirror.omim.org/entry/603112
• UniProt: http://www.uniprot.org/uniprot/P80511.html