advanced glycosylation end product [AGE] receptor (AGER, RAGE)

Function

• mediates interactions of advanced glycosylation end products (AGE)
• receptor for amyloid beta peptide

Structure

• contains 2 Ig-like C2-type domain (immunoglobulin-like)
• contains 1 Ig-like V-type domain (immunoglobulin-like)

Compartment

• isoform 1: cell membrane
• isoform 2: secreted

Alternative splicing

named isoforms=2

Expression

• endothelial cells
• microglia also show strong expression of RAGE

Pathology

• in Alzheimer's disease, RAGE expression is increased especially in neurons close to amyloid deposits & those containing neurofibrillary tangles
• RAGE binds to the amyloid beta-peptide

More general terms

• cell surface receptor

Additional terms

• advanced glycation endproduct (AGE) pigment
• Alzheimer's disease (AD)
• MAPK/MAK/MRK overlapping kinase; MOK protein kinase; renal tumor antigen 1; RAGE-1 (RAGE, MOK, RAGE1)
• microglia (Hortega cell)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:177
• OMIM: https://mirror.omim.org/entry/600214
• UniProt: http://www.uniprot.org/uniprot/Q15109.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=177