MAPK/MAK/MRK overlapping kinase; MOK protein kinase; renal tumor antigen 1; RAGE-1 (RAGE, MOK, RAGE1)

Function

• able to phosphorylate several exogenous substrates & to undergo autophosphorylation (putative)
• phosphorylation appears to increase enzymatic activity
• autophosphorylated (putative)

Structure

• belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily
• contains 1 protein kinase domain

Compartment

cytoplasm (putative)

Alternative splicing

named isoforms=4

Expression

• expressed in heart, brain, lung, kidney, & pancreas
• expressed at very low levels in placenta, liver & skeletal muscle
• not expressed in retina

More general terms

• serine/threonine kinase

Additional terms

• advanced glycosylation end product [AGE] receptor (AGER, RAGE)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5891
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5891
• OMIM: https://mirror.omim.org/entry/605762
• UniProt: http://www.uniprot.org/uniprot/Q9UQ07.html