ubiquitin-conjugating enzyme E2 D1; stimulator of Fe transport; SFT; UBC4/5 homolog; UbcH5; ubiquitin carrier protein D1; ubiquitin-conjugating enzyme E2(17)KB 1; ubiquitin-conjugating enzyme E2-17 kD 1; ubiquitin-protein ligase D1 (UBE2D1 SFT UBC5A UBCH5 UBCH5A)

Function

• accepts ubiquitin from the E1 complex & catalyzes its covalent attachment to other proteins
• in vitro catalyzes Lys-48-linked polyubiquitination
• mediates selective degradation of short-lived & abnormal proteins
• role in E6/E6-AP-induced ubiquitination of p53/TP53
• mediates ubiquitination of PEX5 & auto-ubiquitination of STUB1, TRAF6 & TRIM63/MURF1
• ubiquitinates STUB1-associated HSP90AB1 in vitro
• lacks inherent specificity for any particular Lys of ubiquitin
• essential for viral activation of IRF3
• mediates polyubiquitination of CYP3A4
• protein modification; protein ubiquitination
• component of an E3 ubiquitin ligase complex containing UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC & TBL1X
• interacts with RNF11

Structure

belongs to the ubiquitin-conjugating enzyme family

Compartment

cytoplasm

Expression

ubiquitous

Pathology

• up-regulated in livers of iron-overloaded patients with hereditary hemochromatosis

More general terms

• ubiquitin-conjugating protein E2 (ubiquitin carrier protein)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7321
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7321
• OMIM: https://mirror.omim.org/entry/602961
• UniProt: http://www.uniprot.org/uniprot/P51668.html