heat shock protein HSP 90-beta; HSP 90; HSP 84 (HSP90AB1, HSP90B, HSPC2, HSPCB)

Function

• molecular chaperone
• as ATPase activity
• phosphorylated upon DNA damage, probably by ATM or ATR
• interacts with TP53/p53 (putative)
• interacts with UNC45A; binding to UNC45A involves 2 UNC45A monomers per HSP90AB1 dimer

Structure

• homodimer.
• belongs to the heat shock protein 90 family

Compartment

• cytoplasm, melanosome
• identified by mass spectrometry in melanosome fractions from stage 1 to stage 4

More general terms

• heat shock protein [hsp]-90

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3326
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3326
• OMIM: https://mirror.omim.org/entry/140572
• UniProt: http://www.uniprot.org/uniprot/P08238.html