F-box-like/WD repeat-containing protein TBL1X; SMAP55; transducin beta-like protein 1X; transducin-beta-like protein 1, X-linked (TBL1X TBL1)

Function

• F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units
• role in transcription activation mediated by nuclear receptors
• component of the N-cor repressor complex
• component of a E3 ubiquitin ligase complex containing UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC & TBL1X
• probably part of other corepressor complexes, that do not contain NCOR1 & NCOR2
• interacts with histones H2B, H3a & H4

Structure

• the F-box-like domain is related to the F-box domain, & apparently displays the same function as component of ubiquitin E3 ligase complexes (putative)
• belongs to the WD repeat EBI family
• contains 1 F-box-like domain
• contains 1 LisH domain
• contains 8 WD repeats

Compartment

nucleus (probable)

Alternative splicing

named isoforms=2

Expression

ubiquitous

More general terms

• F-box & WD-repeat protein

Component of

• N-cor repressor complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6907
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6907
• OMIM: https://mirror.omim.org/entry/300196
• UniProt: http://www.uniprot.org/uniprot/O60907.html