F-box/WD repeat-containing protein 1A; F-box & WD repeats protein beta-TrCP; E3RSIkappaB; pIkappaBalpha-E3 receptor subunit (BTRC, BTRCP, FBW1A, FBXW1A)
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Function
- substrate recognition component of a SCF complex
- recognizes & binds to phosphorylated target proteins
- binds phosphorylated beta-catenin & promotes ubiquitin mediated proteolysis
- may be involved in ubiquitination & subsequent proteasomal degradation through a DBB1-CUL4 E3 ubiquitin-protein ligase
- required for activation of NFKB-mediated transcription by IL1B, MAP3K14, MAP3K1, IKBKB & TNF protein modification
- interacts with phosphorylated ubiquitination substrates SMAD3 & SMAD4
- interacts with phosphorylated ubiquitination substrates CTNNB1, NFKBIA, NFKBIB, NFKBIE, NFKB1/nuclear factor NF-kappa-B p105 subunit, ATF4, CDC25A, DLG1 & FBXO5; the interaction requires phosphorylation of the 2 Ser in the substrates' destruction motif D-S-G-X(2,3,4)-S
- binds UBQLN1
- interacts with CDC34 & UBE2R2
- interacts with HIV-1 Vpu
- interacts with FBXW11
- interacts with CUL4A & DDB1
- part of a SCF(BTRC)-like complex lacking CUL1, which is associated with phosphorylated NKBIA & RELA; RELA interacts directly with NFKBIA
Structure
- contains 1 F-box domain
- contains 7 WD repeats
Compartment
Alternative splicing
named isoforms=2
More general terms
Component of
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q9Y297.html
- ↑ Atlas of Genetics & Cytogenetics in Oncology & Haematology http://atlasgeneticsoncology.org//genes/BTRCID451ch10q24.html
- ↑ Matsuzawa SI & Reed JC. Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses. Molecular Cell 7:915-26, 2001 PMID: https://www.ncbi.nlm.nih.gov/pubmed/11389839