ubiquitin-conjugating enzyme E2 R2 (ubiquitin-protein ligase R2, ubiquitin carrier protein R2, E2-CDC34B, UBE2R2, CDC34B, UBC3B)

Function

• catalyzes covalent attachment of ubiquitin to other proteins
• role in degradation of katenin
• ubiquitin conjugation, 2nd step
• when phosphorylated, interacts with beta-TrCP (BTRC)

ATP + ubiquitin + protein lysine
             <-->
AMP + diphosphate + protein N-ubiquityllysine

Structure

belongs to the ubiquitin-conjugating enzyme family

More general terms

• ubiquitin-conjugating protein E2 (ubiquitin carrier protein)
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q712K3.html