NF-kappaB inhibitor epsilon; NF-kappa-BIE; I-kappa-B-epsilon; IkappaBepsilon; IkB-epsilon; IkB-E (NFKBIE, IKBE)

Function

• inhibits NF-kappa-B by complexing with & trapping it in the cytoplasm
• inhibits DNA-binding of NF-kappa-B p50/NF-kappa-B p65 & p50-c-Rel complexes
• interacts with RELA, REL, NFKB1 nuclear factor NF-kappa-B p50 subunit & NFKB2 nuclear factor NF-kappa-B p52 subunit
• Ser phosphorylated; followed by proteasome-dependent degradation

Structure

• belongs to the NF-kappa-B inhibitor family
• contains 6 ANK repeats

Compartment

cytoplasm (putative)

Expression

• highly expressed in spleen, testis & lung, followed by kidney, pancreas, heart, placenta & brain
• also expressed in granulocytes & macrophages

More general terms

• IKB protein
• phosphoprotein
• human longevity protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4794
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4794
• OMIM: https://mirror.omim.org/entry/604548
• UniProt: http://www.uniprot.org/uniprot/O00221.html